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1 issue linked to the use of the chromogenic process is definitely the development of a precipitate following the addition of acid to prevent shade growth. Items that need a neutral or simple pH for solubility are most probably to result in this problem.
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With regard to manufacturing equipment and transfer traces, depyrogenation by dilution has generally been the strategy of choice. Utilization of solid alkali or oxidizing Answer has once in a while been utilized to lower pyrogens in these storage/shipping and delivery devices.
Whilst lots of suppliers are working with LAL, there are still some manufacturers who're unwilling to use LAL as it is too sensitive.
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